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Browsing by Author Lubula, Mulu Y

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  • OER000000673.pdf.jpg
  • Journal article

  • Structural insights into the recognition of mono- and di-acetylated histones by the ATAD2B bromodomain

    • Authors : Lloyd, Jonathan T; McLaughlin, Kyle; Lubula, Mulu Y (2020)

  • Bromodomains are chromatin reader modules that recognize acetylated lysine. Different bromodomains exhibit a preference for specific patterns of lysine acetylation marks on core and variant histone proteins, however, the functional relationships that exist between histone acetyllysine ligands and bromodomain recognition remain poorly understood. In this study, we examined the ligand specificity of the ATAD2B bromodomain and compared it to its closely related paralog in ...
  • OER000000675.pdf.jpg
  • Journal article

  • The BRPF1 bromodomain is a molecular reader of di-acetyllysine

    • Authors : Obi, Juliet O; Lubula, Mulu Y; Cornilescu, Gabriel (2020)

  • Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ (monocytic leukemic zinc-finger protein) HAT (histone acetyltransferase) complex, which is associated with chromosomal translocations known to contribute to the development of acute myeloid leukemia (AML). BRPF1&#...