Browse

Author Profile

Browsing by Author Malcolm, Tess R.

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • OER000000194.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Mapping the substrate sequence and length of the Plasmodium M1 and M17 aminopeptidases

    • Authors : Malcolm, Tess R. (2020)

  • To profile the substrate specificity fingerprints and kinetic behaviors of M1 and M17 aminopeptidases from Plasmodium falciparum and Plasmodium vivax, and the mouse model species, Plasmodium berghei; although the Plasmodium M1 aminopeptidases share a largely similar, broad specificity at the P1 position, the P. falciparum M1 displays the greatest diversity in specificity and P. berghei M1 showing a preference for charged P1 residues. In contrast, the Plasmodi...
  • OER000000198.pdf.jpg
  • Journal article

  • Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from Plasmodium alciparum and Plasmodium vivax

    • Authors : Malcolm, Tess R.; Belousoff, Matthew J.; Venugopal, Hariprasad (2020)

  • The active site metal ions essential for catalytic activity have a secondary structural role mediating the formation of active hexamers. We found that PfA-M17 and Pv-M17 exist in a metal-dependent dynamic equilibrium between active hexameric species and smaller inactive species, that can be controlled by manipulating the identity and concentration of metal ions available. Mutation of residues involved in metal ion binding impaired catalytic activity and the&#...