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Browsing by Author Malinen, Anssi M.

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  • OER000003002.pdf.jpg
  • Journal article

  • The formation of the bacterial RNA polymerase–promoter open complex involves a branched pathway

    • Authors : Malinen, Anssi M. (2021)

  • The expression of most bacterial genes commences with the binding of RNA polymerase (RNAP)–s70 holoenzyme to the promoter DNA. This initial RNAP–promoter closed complex undergoes a series of conformational changes, including the formation of a transcription bubble on the promoter and the loading of template DNA strand into the RNAP active site; these changes lead to the catalytically active open complex (RPO) state. Recent cryo-electron mic...