Journal articleAuthors : Mann, Mandeep K (2021)
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-
targeting chemical probe has been reported to date. Here, we present the progression of a chemical series
that occupies the C-terminal ubiquitin-binding site of a poorly characterized zinc-finger ubiquitin binding
domain (ZnF-UBD) of USP5 and allosterically inhibits the catalytic activity of the enzyme. Systematic
exploration of&... 
