Journal articleAuthors : Mitchell III, David (2023)
Chemical probing experiments have transformed RNA structure analysis, enabling highthroughput
measurement of base-pairing in living cells. Dimethyl sulfate (DMS) is one of
the most widely used structure probing reagents and has played a prominent role in
enabling next-generation single-molecule probing analyses. However, DMS has
traditionally only been able to probe adenine and cytosine nucleobases. We previously
showed that, using appropriate conditions,... 
