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Browsing by Author Mitra, Connie

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Journal article

Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids

Authors : Mitra, Connie (2023)

V-ATPases are highly conserved multi-subunit enzymes that maintain the distinct pH of eukaryotic organelles. The integral membrane a-subunit is encoded by tissue and organelle specific isoforms, and its cytosolic N-terminal domain (aNT) modulates organelle specific regulation and targeting of V-ATPases. Organelle membranes have specific phosphatidylinositol phosphate (PIP) lipid enrichment linked to maintenance of organelle pH. In yeast, the aNT domains of&#x...