Browse

Author Profile

Browsing by Author Newell, Clare L

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • OER000004039.pdf.jpg
  • Journal article

  • Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues

    • Authors : Newell, Clare L; Vorng, Jean-Luc; MacRae, James I (2019)

  • OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. Here we report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS decreases ion-beam induced fragmentation, allowing large molecules such as triglycerides to be more reliably identified. It also increases chemical coverage to include biomolecules wit...