Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Tác giả Ngo, Tony

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000000950.pdf.jpg
  • Journal article

  • Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

    • Tác giả : Ngo, Tony; Stephens, Bryan S; Gustavsson, Martin (2020)

  • Reporting the discovery of the geometry of the complex between full-length CXCR4, a prototypical CXC receptor and driver of cancer metastasis, and its endogenous ligand CXCL12. By comprehensive disulfide crosslinking, we establish the existence and the structure of a novel interface between the CXCR4 distal N-terminus and CXCL12 β1-strand, while also recapitulating earlier findings from NMR, modeling and crystallography of homologous receptors. A crosslinking-informed ...
  • OER000000279.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

    • Tác giả : J. Coleman, James L; Ngo, Tony (2020)

  • GPR37L1 is an orphan G protein-coupled receptor expressed exclusively in the brain and linked to seizures, neuroprotection and cardiovascular disease. Based upon the observation that fragments of the GPR37L1 N-terminus are found in human cerebrospinal fluid, we hypothesized that GPR37L1 was subject to post-translational modification. Heterologous expression of GPR37L1-eYFP in either HEK293 or U87 glioblastoma cells yielded two cell surface species of approximately equivalen...