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Browsing by Author Orsburn, Benjamin C.

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Journal Article

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γsecretase impairing downstream cell signaling

Authors : Orsburn, Benjamin C. (2023)

A recent study demonstrated a substantial signal increase when employing a 0.5% acetic acid buffer additive instead of the traditional 0.1% formic acid used in shotgun proteomics. In this study I compare these two buffers for a dilution series of tryptic digests down to 20 picograms peptide on column on a TIMSTOF single cell proteome (SCP) system. I observe a comparable relative level of signal increase as previously reported...

Journal article

Analysis of single cells treated with the KRASG12D inhibitor MRTX 1133 reveals new challenges for the emerging field of single cell proteomics

Authors : Orsburn, Benjamin C. (2023)

Mutations in KRAS are common drivers of human cancers and are often those with the poorest overall prognosis for patients. A recently developed compound, MRTX1133 has shown promise in inhibiting the KRASG12D mutant protein, which is a primary driver mutation in pancreatic cancer cases worldwide. In this study, I performed a multi-omic analysis of four cancer cell lines following acute treatment with this compound. To obtain increased&#...