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  • OER000000926.pdf.jpg
  • Journal article

  • Glycoproteomic measurement of site-specific polysialylation

    • Authors : Pelingon, Ruby; Pegg, Cassandra L; Zacchi, Lucia F (2020)

  • Polysialylation is the enzymatic addition of a highly negatively charged sialic acid polymer to the non-reducing termini of glycans. Polysialylation plays an important role in development, and is involved in neurological diseases, neural tissue regeneration, and cancer. Polysialic acid (PSA) is also a biodegradable and non-immunogenic conjugate to therapeutic drugs to improve their pharmacokinetics. PSA chains vary in length, composition, and linkages, while the specif...