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Browsing by Author Ragotte, Robert J.

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  • OER000003044.pdf.jpg
  • Journal article

  • Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

    • Authors : Ragotte, Robert J. (2021)

  • Basigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well-established role in Plasmodium falciparum malaria infection of human erythrocytes where it is bound by one of the parasite’s invasion ligands, reticulocyte binding protein homolog 5 (RH5). Here, we sought to validate the claim that the receptor binding domain (RBD) of SARS-CoV-2 spike glycoprotein can form a complex with basigi...