Journal ArticleAuthors : Schachner, Luis F. (2023)
Glycosylated biotherapeutics are an emerging class of drugs with high molecular
heterogeneity, which can affect their safety and efficacy. Characterizing this
heterogeneity is crucial for drug development and quality assessment, but existing
methods are limited in their ability to analyze intact glycoproteins. Here, we present a
new approach to glycoform fingerprinting that uses proton-transfer charge-reduction
with gas-phase fractionation to analyze intact&#... 
