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Browsing by Author Schwartz, Thomas U

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  • OER000000369.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structural analysis of different LINC complexes reveals distinct binding modes

    • Authors : Cruz, Victor E; Schwartz, Thomas U (2020)

  • Linker of nucleoskeleton and cytoskeleton (LINC) complexes are molecular tethers that span the nuclear envelope (NE) and physically connect the nucleus to the cytoskeleton. They transmit mechanical force across the NE in processes such as nuclear anchorage, nuclear migration, and homologous chromosome pairing during meiosis. LINC complexes are composed of KASH proteins traversing the outer nuclear membrane, and SUN proteins crossing the inner nuclear membrane. Hum...
  • OER000000367.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structure of the yeast Nup84-Nup133 complex details flexibility and reveals universal conservation of the membrane anchoring ALPS motif

    • Authors : Nordeen, Sarah A; Turman, Daniel L; Schwartz, Thomas U (2020)

  • The hallmark of the eukaryotic cell is the complex endomembrane system that compartmentalizes cellular functions. Transport into and out of the nucleus, occurs through the Nuclear Pore Complex (NPC). The heptameric Nup84 or Y complex is an essential scaffolding component of the NPC. Here we report two nanobody-bound structures: the full-length Nup84-Nup133 C-terminal domain complex and the Nup133 N-terminal domain, both from S. cerevisiae. Together with previ...