Duyệt theo

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Tìm kiếm theo: Tác giả Seth, Anubha

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  • OER000002745.pdf.jpg
  • Journal article

  • Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

    • Tác giả : Seth, Anubha (2023)

  • Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical 29 membrane domains which are isoform-specifically conserved. Previously we proposed that these 30 membrane domains are orphan receptors (10.7554/eLife.13098; 10.1016/j.cellsig.2020.109538). 31 Lipids extracted from fetal bovine serum at pH 1 inhibited several mAC activities. Guided by a 32 lipidomic analysis we tested glycerophospholipids as potential ligands. Contrary to expectations 33 we s...