Browsing by Author Shem, Karina Mondragon

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  • OER000000390.pdf.jpg
  • Periodicals (Báo – Tạp chí)


  • Authors : Shem, Karina Mondragon; Kish, Katherine Wongtrakul; Kozak, Radoslaw P (2020)

  • During Leishmania transmission sand flies inoculate parasites and saliva into the skin of vertebrates. Saliva has anti-haemostatic and anti-inflammatory activities that evolved to facilitate bloodfeeding, but also modulate the host’s immune responses. Sand fly salivary proteins have been extensively studied, but the nature and biological roles of protein-linked glycans remain overlooked. Here, we characterised the profile of N-glycans from the salivary glycoproteins of Lutz...

  • OER000000281.pdf.jpg
  • Periodicals (Báo – Tạp chí)


  • Authors : Kozak, Radoslaw P; Shem, Karina Mondragon; Williams, Christopher (2020)

  • African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which reduces its anti-hemostatic and anti-clotting properties. To better understand trypanosome transmission and the possible role of glycans in insect bloodfeeding, we characterized the N-glycome of tsetse saliva glycoproteins. Tsetse salivary N-g...