Journal articleAuthors : Sim, Sue Im (2021)
Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently,
how polyamines are transported across membranes is not understood. Recent studies have suggested
that ATP13A2 and its close homologs, collectively known as P5B-ATPases, are polyamine transporters at
endo-/lysosomes. Loss-of-function mutations of ATP13A2 in humans cause hereditary early-onset
Parkinson’s disease. To understand the polyamine ... 
