Journal ArticleAuthors : Swift, Lonnie P. (2023)
DNA double-strand breaks (DSBs) are one of the most cytotoxic forms of damage, with even
small number of unrepaired breaks being potentially lethal1. In human cells, the majority of
DSBs are resolved by one of two pathways, that is non-homologous end-joining (active from
G1- through to the G2-phase of the cell cycle) or homologous recombination (which is
activated as cells traverse S-phase)2. Prior to completion of DSB repair,... 
