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  • OER000002953.pdf.jpg
  • Journal article

  • Binding mechanism underlying FIH-1 suppression caused by the N-terminal disordered region of Mint3

    • Authors : Ten, Tensho (2021)

  • Mint3 is known to enhance aerobic ATP production, known as the Warburg effect, by binding to FIH-1. Since this effect is considered to be beneficial for cancer cells, the interaction is a promising target for cancer therapy. However, previous research has suggested that the interacting region of Mint3 with FIH-1 is intrinsically disordered, which makes investigation of this interaction challenging. Therefore, we adopted a physicochemical approach that co...