Journal articleAuthors : Trendel, Jakob (2023)
Ribosomes are among the most abundant and complex machineries in the cell, however, the turnover 15 of their subunits remains poorly understood. Here, we apply proteomic flux and cryo-electron 16 microscopy analyses to interrogate the ribosome life cycle in human cells. We show that subpopulations 17 of ribosomal subunits coexist, which vary in turnover kinetics and structure. Specifically, 80S ribosomes 18 have a much longer half-life than free 40S... 
