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Browsing by Author W, Koelmel

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  • OER000004025.pdf.jpg
  • Journal article

  • The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair

    • Authors : JT, Barnett; J, Kuper; W, Koelmel (2019)

  • Nucleotide excision repair (NER) protects the genome following exposure to diverse types of DNA damage, including UV light and chemotherapeutics. Mutations in mammalian NER genes lead to diseases such as xeroderma pigmentosum, trichothiodystrophy, and Cockayne syndrome. In eukaryotes, the major transcription factor TFIIH is the central hub of NER. The core components of TFIIH include the helicases XPB, XPD, and five ‘structural’ subunits. Two of these structu...