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Browsing by Author bradshaw, william j

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  • OER000002292.pdf.jpg
  • Journal Article

  • Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

    • Authors : bradshaw, william j (2023)

  • SH2-containing-inositol-5-phosphatases (SHIP1 and SHIP2) are key parts of the PI3K/AKT/mTOR signalling pathway. SHIPs dephosphorylate phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) to produce phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). The balance between these two second messengers and related inositol- and phosphatidylinositol phosphates (PIPs) ultimately affects a wide number of cellular processes including inflammation, autophagy, cell migration, metabolism and cell growth.1,2 Therefore, it is&...