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  • OER000002507.pdf.jpg
  • Journal article

  • Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids

    • Authors : Mitra, Connie  (2023)

  • V-ATPases are highly conserved multi-subunit enzymes that maintain the distinct pH of eukaryotic organelles. The integral membrane a-subunit is encoded by tissue and organelle specific isoforms, and its cytosolic N-terminal domain (aNT) modulates organelle specific regulation and targeting of V-ATPases. Organelle membranes have specific phosphatidylinositol phosphate (PIP) lipid enrichment linked to maintenance of organelle pH. In yeast, the aNT domains of&#x...
  • OER000002729.pdf.jpg
  • Journal article

  • Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms

    • Authors : Selvaraj, Muniyandi (2023)

  • The actin cytoskeleton is critical for cell migration, morphogenesis, endocytosis, organelle dynamics, and cytokinesis. To support diverse cellular processes, actin filaments form a variety of structures with specific architectures and dynamic properties. Key proteins specifying actin filaments are tropomyosins. Non-muscle cells express several functionally non-redundant tropomyosin isoforms, which differentially control the interactions of other proteins, including myosins ...