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Browsing by Subject đồng phân Pannexin

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Journal article

Structural insights into the organization and channel properties of human Pannexin isoforms 1 and 3

Authors : Hussain, Nazia (2023)

Pannexins are single-membrane large-pore ion channels that release ATP upon activation. Three isoforms of pannexins, 1, 2, and 3, perform diverse cellular roles, including inflammation, differentiation, neuropathic pain, and ATP release. In this study, we report the cryoEM structure of pannexin 3 at 3.9 Å and characterize the structural differences with pannexin isoforms 1 and 2. We observe the organization of the Pannexin 3 vestibule into&...