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Showing results 1 to 4 of 4
  • OER000002582.pdf.jpg
  • Journal article

  • Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae

    • Authors : Pis Diez, Cristian M. (2023)

  • The vertebrate host's immune system and resident commensal bacteria deploy a range of highly reactive small molecules that provide a barrier against infections by microbial pathogens. Gut pathogens, such as Vibrio cholerae, sense and respond to these stressors by modulating the expression of exotoxins that are crucial for colonization. Here, we employ mass-spectrometry-based profiling, metabolomics, expression assays and biophysical approaches to show that transcription...
  • OER000002603.pdf.jpg
  • Journal article

  • Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae

    • Authors : Pis Diez, Cristian M. (2023)

  • The vertebrate host's immune system and resident commensal bacteria deploy a range of highly reactive small molecules that provide a barrier against infections by microbial pathogens. Gut pathogens, such as Vibrio cholerae, sense and respond to these stressors by modulating the expression of exotoxins that are crucial for colonization. Here, we employ mass-spectrometry-based profiling, metabolomics, expression assays and biophysical approaches to show that transcription...
  • OER000002679.pdf.jpg
  • Journal article

  • Metabotyping of Andean pseudocereals and characterization of emerging mycotoxins

    • Authors : Ocmín, Pedro G. Vásquez- (2023)

  • Pseudocereals are best known for three crops derived from the Andes: quinoa (Chenopodium quinoa, 29 Chenopods I), canihua (C. pallidicaule, Chenopods I), and kiwicha (Amaranthus caudatus). Their grains 30 are recognized for their nutritional benefits; however, there is a higher level of polyphenism and the 31 chemical foundation that would rely with such polyphenism has not been thoroughly investigated. 32 Meanwhile, the chemical food safety of pseudoce...
  • OER000002976.pdf.jpg
  • Journal article

  • Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane penetrating loop

    • Authors : Hoelzgen, Fabian (2021)

  • Anthrax infection is associated with severe illness and high mortality. Protective antigen (PA) is the central component of the anthrax toxin, which is the main virulent factor of anthrax. Upon endocytosis, PA opens a pore in the membranes of endosomes, through which the toxin's cytotoxic enzymes are extruded. The PA pore is formed by a cooperative conformational change where PA's membrane-penetrating loops associate, forming a hydrophobic rim th...