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Journal Article

Rational engineering of binding pocket’s structure and dynamics in penicillin G acylase for selective degradation of bacterial signaling molecules

Authors : Grulich, Michal (2023)

The rapid increase in antibiotic-resistant bacteria and the inability to provide new generations of potent antimicrobials necessitates the search for new, unconventional solutions. Methods based on targeting bacterial communication induced by signaling molecules, known as quorum sensing, are gaining increasing interest. Quorum quenching (QQ), as the process of interrupting this communication is called, can be achieved by enzymatic degradation of signaling molecules and repr...