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Journal article

Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides

Authors : Saad, Hamada (2023)

Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number of secondary modifications have been described that further decorate lasso peptide scaffolds. Using genome mining, we have discovered a pair of lasso peptide biosynthetic gene clusters (BGCs) that include cytochrome P450 genes. Here, we report the structural characterizat...

Journal Article

The GEF Cdc24 and GAP Rga2 synergistically regulate Cdc42 GTPase cycling

Authors : Tschirpke, Sophie (2023)

Establishing cell polarity is vital for cells, as it is required for cell division, directed growth and secretion, and motility. A well-studied model organism for polarity establishment is Saccharomyces cerevisiae: here the small Rho-type GTPase Cdc42 exits the cytoplasm and accumulates in one spot on the cell membrane, marking the site of bud emergence. Due to redundancy and interconnection within the regulatory network surrounding Cdc42, the&#x...