Journal ArticleAuthors : Gibson, William J. (2023)
The aberrant localization of proteins in cells is a key factor in the development of various diseases, including
cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization
for therapeutic purposes, we engineered bifunctional compounds that bind to proteins in separate cellular
compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuclear-localized
BRD4 as a “carrier” for co-... 
