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Journal article

A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

Authors : George, Amy L. (2023)

Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide interactions of small therapeutic molecules and their target and off-target proteins, complementing phenotypic-based drug screens. Detecting differences in thermal stability due to target engagement requires high quantitative accuracy and consistent detection. Isobaric tandem mass tags (TMT) are used to multiplex samples and increase quantification precision in TPP analysis by data-dependent acqui...

Journal article

AlphaPeptStats: an open-source Python package for automated, scalable and industrial-strength statistical analysis of mass spectrometry-based proteomics

Authors : Krismer, Elena (2023)

The widespread application of mass spectrometry (MS)-based proteomics in biomedical research increasingly requires robust, transparent and streamlined solutions to extract statistically reliable insights. Existing, popular tools were generally developed for specific uses in academic environments and did not fully embrace current open-source principles and best practices of software engineering. We have designed and implemented AlphaPeptStats, an inclusive python package with broad&#...