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  • OER000002720.pdf.jpg
  • Journal article

  • Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes

    • Authors : Keymakh, Margaret (2023)

  • Homologous recombination (HR) is a double-strand break DNA repair pathway that preserves chromosome structure. To repair the damaged recipient DNA, HR requires an intact donor DNA sequence located elsewhere in the genome. After the double-strand break is repaired, DNA sequence information can be transferred between donor and recipient DNA molecules through different mechanisms, including DNA crossovers that form between homologous chromosomes. Regulating...
  • OER000002620.pdf.jpg
  • Journal article

  • The most probable ancestral sequence reconstruction yields proteins without systematic bias in thermal stability or activity

    • Authors : Sennett, Michael A. (2023)

  • Ancestral sequence resurrection (ASR) is the inference of extinct biological sequences from extant sequences, the most popular of which are based on probabilistic models of evolution. ASR is becoming a popular method for studying the evolution of enzyme characteristics. The properties of ancestral enzymes are biochemically and biophysically characterized to gain some knowledge regarding the origin of some enzyme property. Current methodology relies on resurrection ...