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  • OER000003019.pdf.jpg
  • Journal article

  • AKAP79 enables calcineurin to directly suppress protein kinase A activity

    • Authors : Church, Timothy W. (2021)

  • Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about changes including synaptic long-term depression (LTD). AKAP79 supports signaling of this type by anchoring PKA and calcineurin in tandem. In this study, we discove...