Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề ATP

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002780.pdf.jpg
  • Journal article

  • ATP dependent polymerization dynamics of bacterial actin proteins involved in Spiroplasma swimming

    • Tác giả : Takahashi, Daichi (2023)

  • MreB is a bacterial protein belonging to the actin superfamily. It polymerises into an antiparallel double-stranded filament that generally functions in cell shape determination by maintaining cell wall synthesis. Spiroplasma eriocheiris, a helical wall-less bacterium, has five classes of MreB homologs (SpeMreB1-5) that are likely to be involved in swimming motility. Here, we investigated the structure, ATPase activity, and polymerisation dynamics of SpeMreB3 and ...
  • OER000004056.pdf.jpg
  • Journal article

  • Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat

    • Tác giả : Veliova, Michaela; Ferreira, Caroline M; Benador, Ilan Y (2019)

  • Futile lipid cycling is an ATP-wasting process proposed to participate in energy expenditure of mature fat-storing white adipocytes, given their inability to oxidize fat. The hallmark of activated brown adipocytes is to increase fat oxidation by uncoupling respiration from ATP synthesis. Whether ATP-consuming lipid cycling can contribute to BAT energy expenditure has been largely unexplored. Here we find that pharmacological inhibition of the mitochondrial pyruvate...
  • OER000000669.pdf.jpg
  • Journal article

  • Crystal Structure of the Werner’s Syndrome Helicase

    • Tác giả : Newman, Joseph A; Gavard, Angeline E; Lie, Simon (2020)

  • Werner syndrome helicase (WRN) plays important roles in multiple pathways of DNA repair and the maintenance of genome integrity. Recently, loss of WRN was identified as a strong synthetic lethal interaction for microsatellite instable (MSI) cancers making WRN a promising drug target. Yet, structural information for the helicase domain is lacking, which prevents structure-based design of drug molecules. In this study, we show that ATP binding and hydrolys...
  • OER000000827.pdf.jpg
  • Journal article

  • Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors

    • Tác giả : Asquith, Christopher R. M; Tizzard, Graham J; Bennett, James M (2020)

  • Water networks within kinase inhibitor design and more widely within drug discovery are generally poorly understood. The successful targeting of these networks prospectively has great promise for all facets of inhibitor design, including potency and selectivity on target. Here we describe the design and testing of a targeted library of 4-anilinoquinolines for use as inhibitors of cyclin G associated kinase (GAK). The GAK cellular target engagement assays,...