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  • OER000000250.pdf.jpg
  • Journal article

  • Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

    • Authors : Held, Ntsiki M.; Buijink, M. Renate; Elfrink, Hyung L. (2020)

  • To investigate whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 hour lipid profiles of WAT and BAT using a global lipidomics analysis of >1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~22% of the analyzed lipids were considered rhythmic...
  • OER000000343.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

    • Authors : Roger, Friederike; Picazo, Cecilia; Reiter, Wolfgang (2020)

  • Peroxiredoxins are H2O2 scavenging enzymes that also carry H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction. We show here that Tsa1 effects both these functions not by scavenging H2O2, but by repressing the nutrient signaling Ras-cAMP-PKA pathway at the level of the protein kinase A (PKA) enzyme. Tsa1 stimulates sulfe...