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  • OER000000278.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missorting

    • Authors : Schützmann1, Marie P; Hasecke, Filip; Bachmann, Sarah (2020)

  • Amyloid-β peptide (Aβ) forms metastable oligomers >50 kD, termed AβOs or protofibrils, that are more effective than Aβ amyloid fibrils at triggering Alzheimer’s disease-related processes such as synaptic dysfunction and Tau pathology, including Tau mislocalization. In neurons, Aβ accumulates in endo-lysosomal vesicles at low pH. Here, we show that the rate of AβO assembly is accelerated 8,000-fold upon pH reduction from extracellular to endo-lysosomal pH, at&#x...
  • OER000004045.pdf.jpg
  • Journal article

  • High Throughput Screening at the Membrane Interface Reveals New Inhibitors of Amyloid-β

    • Authors : Cox, Sarah J; Lam, Brian; Prasad, Ajay (2019)

  • Amyloid-β aggregation at the cell-membrane of neruonal cells is implicated as a source of toxicity for Alzheimer’s disease. Small molecules have been studied for their ability to supress amyloid aggregation and toxicity, but the presence of membranes negate their activity. Here, we have identified 5 small molecules that are active at the membrane interface.