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Browsing by Subject Autophagy

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  • OER000000801.pdf.jpg
  • Journal article

  • A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

    • Authors : Fracchiolla, Dorotea; Chang, Chunmei; Hurley, James H (2020)

  • Autophagy requires the synthesis of PI(3)P and the conjugation of LC3 to the phagophore membrane. We reconstituted these two reactions and their coupling by WIPI2, and showed that positive feedback between PI3KC3-C1 and WIPI2 leads to rapid LC3 lipidation by the ATG16L1 complex.
  • OER000000651.pdf.jpg
  • Journal article

  • Alzheimer cells on their way to derailment show selective changes in protein quality control network

    • Authors : Koopman, Margreet B (2020)

  • Alzheimer’s Disease is driven by protein aggregation and is characterised by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the question to which extent this control is disturbed in disease. Here we describe that brain cells in Alzheimer’s Disease show very specific derailment of the protein quality control network. We performed a...