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  • OER000002539.pdf.jpg
  • Journal article

  • Affinity-ranking BIN1 interactions underpinning centronuclear myopathy

    • Authors : Zambo, Boglarka  (2023)

  • Deletion of the protein-protein interaction SH3 domain of the membrane remodeling amphiphysin 2 (BIN1) protein was found to lead to centronuclear myopathy in patients, yet only few interaction partners of BIN1 SH3 have been identified so far, precluding a better understanding of the pathomechanism. Here we used the holdup assay to proteome-wide measure steady-state affinity constants of BIN1 SH3 domain for thousands of full-length cellular...