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  • OER000002695.pdf.jpg
  • Journal article

  • Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation

    • Authors : Jones, Joshua D. (2023)

  • Chemical modifications to protein encoding messenger RNA (mRNA) can modulate their localization, translation and stability within cells. Over 15 different types of mRNA modifications have been identified by sequencing and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) technologies. While LC-MS/MS is arguably the most essential tool available for studying analogous protein post-translational modifications, the high-throughput discovery and quantitative characteri...