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Journal Article

CK1δ homeostasis by activity-dependent shuttling and degradation of orphan kinase

Authors : Serrano, Fidel E. (2023)

Casein kinase 1δ (CK1δ) is a simple monomeric enzyme involved in the regulation of a variety of functions, including signal transduction, the circadian clock, and the cell cycle. Although CK1δ is targeted by the ubiquitin ligase APC/CCdh1 is not understood how CK1δ expression is regulated to support its multiple functions. Here, we show that kinase activity controls CK1δ homeostasis by coordinating two competing processes: export ...

Journal article

Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

Authors : Kuna, Ramya S (2023)

Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several25 organelle-specific pathways are available for provision of acetyl-CoA as nutrient availability26 fluctuates, so understanding how cells maintain acetyl-CoA flux under such stresses is critically27 important. To this end we applied 13 C isotope tracing cell lines deficient in these mitochondrial28 (ATP-citrate lyase; ACLY-), cytosolic, (acetyl-CoA synthetase (ACSS2-), and...

Journal Article

Robust Homeostasis of Cellular Cholesterol via Antithetic Integral Control

Authors : Scheepers, Ronél (2023)

Although cholesterol is essential for cellular viability and proliferation, it is highly toxic in excess. The concentration of cellular cholesterol must therefore be maintained within tight tolerances, and is thought to be subject to a stringent form of homeostasis known as Robust Perfect Adaptation (RPA). While much is known about the cellular signalling interactions involved in cholesterol regulation, the specific chemical reaction network structur...