Journal articleAuthors : Belyy, Alexander (2023)
Tc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of
these enzymes is TccC3, an ADP-ribosyltransferase from Photorhabdus luminescens.
Once TccC3 is translocated into the target cell, the enzyme ADP-ribosylates actin,
resulting in clustering of the actin cytoskeleton and ultimately cell death. Here, we
combine biochemistry, solution and solid-state NMR spectroscopy and cryo-EM to show
in atomic detail how ... 
