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  • OER000003008.pdf.jpg
  • Journal article

  • Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons

    • Authors : Fujiyama, Keisuke (2021)

  • Molecular chirality, discovered by Louis Pasteur in the middle of the 19th century1, is found 3 in most primary and secondary metabolites. Particularly, the so-called natural products are 4 rich in chiral centres2. The stereochemistry of natural products is strictly recognized in living 5 organisms, and is thus closely related to their biological functions. The Diels–Alder (DA) 6 reaction, which forms a six-membered ring with up to four chiral ...
  • OER000002768.pdf.jpg
  • Journal article

  • Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3B

    • Authors : Bufton, Joshua C. (2023)

  • UPF3B is a key nonsense-mediated mRNA decay (NMD) factor required for surveillance of mRNA and regulation of eukaryotic gene expression. Mutations in UPF3B cause intellectual disability. The underlying molecular mechanisms remain unexplored as the mutations lie in an uncharacterized region of UPF3B. Here, we show that UPF3B shares structural and functional homology to the Drosophila Behavior/Human Splicing protein family comprising an RNA-recognition motif-like domain&...