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Showing results 1 to 6 of 6

Journal article

Crystal structure and biochemical analysis suggest that YjoB ATPase is a substrate-specific molecular chaperone

Authors : Kwon, Eunju (2023)

AAA+ ATPases are ubiquitous proteins associated with most cellular processes, including DNA 15 unwinding and protein unfolding. Their functional and structural properties are typically 16 determined by domains and motifs added to the conserved ATPases domain. Currently, the 17 molecular function and structure of many ATPases remain elusive. Here, we report the crystal 18 structure and biochemical analyses of YjoB, a Bacillus subtilis AAA+ protein. The crystal...

Journal article

Crystal structure and functional peculiarities of a primordial Orange Carotenoid Protein (OCPX)

Authors : Slonimskiy, Yury B. (2023)

The two-domain photoactive Orange Carotenoid Protein (OCP) confers photoprotection in cyanobacteria and presumably stems from domain fusion. Yet, the primitive thylakoid-less cyanobacteria Gloeobacter encodes a complete OCP. Its photosynthesis regulation lacks the so-called Fluorescence Recovery Protein (FRP), which in Synechocystis inhibits OCPmediated phycobilisome fluorescence quenching, and Gloeobacter OCP belongs to the recently defined, heterogeneous clade OCPX (GlOCPX),&#...

Ebooks (Sách điện tử)

Crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

Authors : Gurusaran, Manickam (2023)

The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and movement of nuclear contents. It is formed of nuclear SUN and cytoplasmic KASH proteins, which interact within the nuclear lumen, immediately below the outer nuclear membrane. However, the symmetrical location of KASH molecules within SUN-KASH complexes in previous crystal structures has been difficult to reconcile with the steric requirements for insert...

Periodicals (Báo – Tạp chí)

Mechanism-based inhibitors of SIRT2: structure–activity relationship, Xray structures, target engagement, egulation of a-tubulin acetylation and inhibition of breast cancer cell migration†

Authors : Nielsen, Alexander L. (2020)

Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme. Here,&...

Periodicals (Báo – Tạp chí)

Structural insights on the substrate-binding proteins of the Mycobacterium tuberculosis mammalian-cell-entry (Mce) 1 and 4 complexes

Authors : Asthana, Pooja (2020)

Report the properties of the substrate-binding proteins (SBPs; MceA-F) of the Mce1 and Mce4 complexes from Mtb which are responsible for the import of mycolic acid/fatty acids, and cholesterol respectively. MceA-F are composed of four domains namely, transmembrane, MCE, helical and tail domains. Our studies show that MceA-F are predominantly monomeric when purified individually and do not form homohexamers unlike the reported homologs (MlaD, PqiB and Let...

Periodicals (Báo – Tạp chí)

Structural properties and peptide ligand binding of the capsid homology domains of human Arc

Authors : Hallin1, Erik I.; Clive R., Bramham1; Kursula, Petri (2021)

The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic scaling and the normal function of the brain. Arc interacts with many neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully established. The C-terminal domain of Arc consists of tandem domains, termed the N- and C-lobe. The N-lobe harbours a peptide binding site, able to bind to multiple targets. By measuring the affinity of&#x...