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  • OER000002777.pdf.jpg
  • Journal article

  • HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

    • Authors : Dam, Kim-Marie A. (2023)

  • BG24, a VRC01-class broadly neutralizing antibody (bNAb) against HIV-1 Env with relatively few somatic hypermutations (SHMs), represents a promising target for vaccine strategies to elicit CD4-binding site (CD4bs) bNAbs. To understand how SHMs correlate with BG24 neutralization of HIV-1, we solved 4.1 Å and 3.4 Å single-particle cryo-EM structures of two inferred germline (iGL) BG24 precursors complexed with engineered Env-based immunogens lacking CD4bs N-glycans. St...
  • OER000000721.pdf.jpg
  • Journal article

  • Structural Basis of CD4 Downregulation by HIV-1 Nef

    • Authors : Kwon, Yonghwa; Kaake, Robyn; Echeverria, Ignacia (2020)

  • The HIV-1 protein Nef suppresses multiple immune surveillance mechanisms to promote viral pathogenesis1. Individuals infected with HIV-1 encoding defective nef genes do not develop AIDS for decades2,3. A key target of Nef is the cellular receptor CD4. Although essential for viral entry into host cells, CD4 is problematic for the virus later in its replication cycle: CD4 disrupts processing of the viral glycoprotein, Env, inhibiting infectivity4; it inter...