Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề Cdc42 GTPase

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002333.pdf.jpg
  • Journal Article

  • A guide to the in vitro reconstitution of Cdc42 GTPase activity and its regulation

    • Tác giả : Tschirpke, Sophie (2023)

  • Cdc42 is a small Rho-type GTPase and the main regulator of cell division in eukaryotes. It is surrounded by a large network of regulatory proteins. To understand the processes around cell division, in-depth understanding of Cdc42 and its regulation is required. In vitro reconstitutions are a suitable tool for such detailed mechanistic studies, as they allow a high level of control over the conditions and components used and. For these Cdc4...
  • OER000002372.pdf.jpg
  • Journal Article

  • The GEF Cdc24 and GAP Rga2 synergistically regulate Cdc42 GTPase cycling

    • Tác giả : Tschirpke, Sophie (2023)

  • Establishing cell polarity is vital for cells, as it is required for cell division, directed growth and secretion, and motility. A well-studied model organism for polarity establishment is Saccharomyces cerevisiae: here the small Rho-type GTPase Cdc42 exits the cytoplasm and accumulates in one spot on the cell membrane, marking the site of bud emergence. Due to redundancy and interconnection within the regulatory network surrounding Cdc42, the&#x...