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  • OER000000222.pdf.jpg
  • Journal article

  • Actin-binding compounds that affect the kinetics of the interaction of cardiac myosin with actin

    • Authors : Roopnarine, Osha; Thomas, David D. (2020)

  • the effects of ten actin binding compounds on the interaction of cardiac myosin subfragment 1 (S1) with pyrene labeled F actin (PFA). These compounds, previously identified from a small-molecule high-throughput screen (HTS), perturb the microsecond structural dynamics of actin and the steady-state activity of actin-activated myosin ATPase. In the present study, we have further characterized their mechanisms of action by measuring their effects on PFA fluorescence,...