Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề Cryo-electron microscopy

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Hiển thị kết quả tìm kiếm từ 1 đến 4 trong 4 kết quả phù hợp
  • OER000000920.pdf.jpg
  • Journal article

  • Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin

    • Tác giả : Oda, Toshiyuki; Yanagisawa, Haruaki; Wakabayashi, Takeyuki (2020)

  • Troponin is an essential component of striated muscle and it regulates the sliding of actomyosin system in a calcium-dependent manner. Despite its importance, the structure of troponin has been elusive due to its high structural heterogeneity. In this study, we analyzed the 3D structures of murine cardiac thin filaments using a cryo-electron microscope equipped with a Volta phase plate (VPP). Contrast enhancement by a VPP enabled us to reconstruct&#...
  • OER000000934.pdf.jpg
  • Journal article

  • The Architecture of GluD2 Ionotropic Delta Glutamate Receptor Elucidated by cryo-EM

    • Tác giả : Burada, Ananth Prasad; Kumar, Janesh (2020)

  • GluD2 receptors belong to the orphan delta receptor family of glutamate receptor ion channels. These receptors play key roles in synaptogenesis and synaptic plasticity and are associated with multiple neuronal disorders like schizophrenia, autism spectrum disorder, cerebellar ataxia, intellectual disability, paraplegia, retinal dystrophy, etc. Despite the importance of these receptors in CNS, insights into full-length GluD2 receptor structure is missing till-date. Here we r...
  • OER000000668.pdf.jpg
  • Journal article

  • The cryo-electron microscopy structure of the human CDK-activating kinase

    • Tác giả : Grebera, Basil J; Bertoldic, Juan M. Perez; Limd, Kif (2020)

  • Control of gene expression and the cell cycle is critical for appropriate cell growth and timely cell division. Failure of the mechanisms regulating these processes can result in proliferative diseases. A molecular complex termed the CDK activating kinase (CAK) impinges on both of these regulatory networks in human cells and is thus a possible drug target for treatment of cancer. Here, we use cryo-electron microscopy to describe the detailed mo...
  • OER000000393.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states

    • Tác giả : Santosh, Vishaka; Musayev, Faik; Jaiswal, Rahul (2020)

  • The adeno-associated virus (AAV) Rep proteins use a unique AAA+ domain to catalyze DNA replication, transcription regulation, and genome packaging. Also, they mediate site-specific integration during a latent phase. To understand the mechanisms underlying AAV Rep function, we investigated the cryo-EM and X-ray structures of Rep68-ssDNA complexes. Surprisingly, Rep68 generates hybrid ring structures where the Origin-Binding-Domain (OBD) forms octameric rings while the helicase&#x...