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  • OER000000649.pdf.jpg
  • Journal article

  • A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol

    • Authors : Kash, Kazutoshi; Stojkovič, Gorazd; Ruiz, Cristina Velázquez (2020)

  • Replication forks often stall at damaged DNA. Resumption of DNA synthesis can occur by replacement of the replicative DNA polymerase with specialized, error-prone translesion DNA polymerases (TLS), that have higher tolerance for damaged substrates. Several of these polymerases (Polλ, Polη and PrimPol) are stimulated in DNA synthesis through interaction with PolDIP2, however the mechanism of this PolDIP2-dependent stimulation is still unclear. Here we show that Pri...