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  • Journal article

  • An Improved 4’-Aminomethyltroxsalen-Based DNA Crosslinker for Biotinylation of DNA

    • Authors : Wielenberg, Kevin; Wang, Miao; Yang, Min (2020)

  • Nucleic acid crosslinkers that covalently join commentary strands have applications as both pharmaceuticals and biochemical probes. Psoralen is a popular crosslinker moiety that reacts with double stranded DNA and RNA upon irradiation with long wave UV light. A commercially available compound EZ-Link Psoralen-PEG3-Biotin has been used in many studies to crosslink DNA and double strand RNA for genome-wide investigations. Here we present a novel probe, AP3B, wh...