Journal articleAuthors : Mermans, Daphne (2023)
In recent years, it has become clear that many homo- and heterodimeric cytoplasmic proteins
in both prokaryotic and eukaryotic cells start to dimerize cotranslationally, i.e., while at least
one of the two chains is still attached to the ribosome. Whether this is possible also for
integral membrane proteins is unknown, however. Here, we apply Force Profile Analysis
(FPA) – a method where a translational arrest peptide (AP) enginee...