Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề EsxA:B

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000001599.pdf.jpg
  • Journal article

  • Nα-acetylation of EsxA is required for mycobacterial cytosolic translocation and virulence

    • Tác giả : Aguilera, Javier; Karki, Chitra B; Li, Lin (2020)

  • Mycobacterium tuberculosis virulence factors, EsxA and EsxB, are secreted as a heterodimer (EsxA:B) and play an essential role in mycobacterial phagosomal escape and cytosolic translocation. Current studies support a model that EsxA must dissociate from its chaperon EsxB at low pH in order for EsxA to interact with host membranes. However, the mechanism of the heterodimer separation is not clear. In the present study, we have obtained evidence that&...