Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề GMP synthetase

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000000886.pdf.jpg
  • Journal article

  • Helices on interdomain interface couple catalysis in the ATPPase domain with allostery in Plasmodium falciparum GMP synthetase

    • Tác giả : Shivakumaraswamy, Santosh; Pandey, Nivedita; Ballut, Lionel (2020)

  • GMP synthetase catalyzes the substitution of the C2 oxo-group of the purine base in XMP with an amino-group generating GMP, the last step in the biosynthesis of GMP. This reaction involves a series of catalytic events that include hydrolysis of Gln generating ammonia in the glutamine amidotransferase (GATase) domain, activation of XMP to adenyl-XMP intermediate in the ATP pyrophosphatase (ATPPase) domain and reaction of ammonia with the intermediate ...