Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề GTP

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000000383.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase

    • Tác giả : Takeuchi, Koh; Ikeda, Yoshiki; Harada, Ayaka (2020)

  • Most kinases function with ATP. However, contrary to the prevailing dogma, phosphatidylinositol 5-phosphate 4-kinase β (PI5P4Kβ) utilizes GTP as a primary phosphate donor with a unique binding mode for GTP. Although PI5P4Kβ is evolved from a primordial ATP-utilizing enzyme, PI4P5K, how PI5P4Kβ evolutionarily acquired the GTP preference to function as a cellular GTP sensor remains unclear
  • OER000000851.pdf.jpg
  • Journal article

  • VC1 catalyzes a key step in the biosynthesis of vicine from GTP in faba bean

    • Tác giả : Björnsdotter, Emilie; Nadzieja, Marcin; Chang, Wei (2020)

  • Faba bean is a widely adapted and high-yielding legume cultivated for its protein-rich seeds1. However, the seeds accumulate the anti-nutritional pyrimidine glucosides vicine and convicine, which can cause haemolytic anaemia—favism—in the 400 million individuals genetically predisposed by a deficiency in glucose-6-phosphate dehydrogenase2. Here, we identify the first enzyme associated with vicine and convicine biosynthesis, which we name VC1. We show that VC1 co-locates wit...